How should Levothyroxine Sodium be administered to maximize absorption?

Levothyroxine Sodium is a synthetic form of the thyroid hormone thyroxine (T4) used to treat hypothyroidism. To maximize absorption, it is best administered on an empty stomach, specifically 1 hour before meals or 2 hours after meals. This timing minimizes interference from food, which can significantly affect the absorption of the medication.

Taking levothyroxine with meals can lead to inconsistent plasma levels, as certain food items, particularly those high in fiber, soy products, calcium, and iron, can bind to the medication and reduce its effectiveness. Administering the medication at bedtime may also not provide the best absorption and could lead to variations in thyroid hormone levels depending on the individual’s eating and sleeping patterns. By following the guidance of taking levothyroxine on an empty stomach, patients are more likely to achieve steady and therapeutic hormone levels.