What is a common complication associated with Cushing's Syndrome?

Cushing's Syndrome is characterized by excessive levels of cortisol, which can lead to several complications, one of the most significant being increased calcium resorption from the bones. This occurs due to the impact of elevated cortisol levels on bone metabolism, where there is an increase in the activity of osteoclasts, the cells that break down bone tissue. As a result, this can lead to a decrease in bone density and, consequently, a higher risk of fractures.

This complication is particularly concerning because individuals with Cushing's Syndrome often exhibit other symptoms like obesity and insulin resistance, which together compound the risk of osteoporosis and fractures. Monitoring bone health and calcium intake is essential in the management of patients with Cushing's Syndrome to mitigate this risk.

In contrast, the other options mentioned do not accurately reflect the common consequences associated with this condition. For example, decreased gastric secretions and reduced hepatic gluconeogenesis do not typically occur in Cushing's Syndrome, and improved fat metabolism is contrary to what happens, as fat distribution is often altered, leading to increased abdominal and facial fat.