What is the gold standard medication for treating hypothyroidism?

Levothyroxine sodium is recognized as the gold standard medication for treating hypothyroidism due to its effectiveness and safety profile. It is a synthetic form of the naturally occurring thyroid hormone thyroxine (T4). Levothyroxine is preferred because it closely mimics the body's own T4 production, allowing for optimal metabolism and regulation of energy levels, growth, and development.

This medication has a well-established dosage form, with predictable pharmacokinetics, which makes it easier to monitor and adjust dosages according to individual patient needs. Regular thyroid function tests help guide therapy, ensuring it is effective and minimizing the chances of overdosing or underdosing.

In contrast, other options such as liotrix and liothyronine sodium, although used in certain contexts, do not have the same level of broad applicability or proven outcomes as levothyroxine. Liotrix, a combination of T4 and T3, may not be necessary in many patients, especially when T4 alone adequately addresses hypothyroidism. Similarly, whilst liothyronine sodium (T3) can be used in some cases, it requires careful monitoring and has a shorter half-life, potentially leading to fluctuations in thyroid hormone levels. Thyroid extract, derived from