Which syndrome is characterized by the presence of insulin resistance and excess levels of male hormones?

Polycystic Ovary Syndrome (PCOS) is accurately characterized by the presence of insulin resistance and excess levels of male hormones, known as androgens. This syndrome typically manifests with a range of symptoms including irregular menstrual cycles, acne, hirsutism (excess hair growth), and ovarian cysts. The insulin resistance observed in PCOS often leads to higher insulin levels, which can further exacerbate androgen production by the ovaries.

In contrast, Type 1 Diabetes is primarily an autoimmune condition that leads to the destruction of insulin-producing pancreatic beta cells, resulting in low insulin levels, rather than resistance. Acromegaly is caused by excess growth hormone, usually due to a pituitary tumor, leading to abnormal growth and metabolic changes but not specifically insulin resistance or elevated male hormones. Addison's Disease involves adrenal insufficiency, leading to deficiencies in cortisol and other hormones, but it does not align with the characteristic symptoms of insulin resistance or elevated androgens found in PCOS.

Thus, PCOS stands out as the correct response, linking its key features of insulin resistance and hyperandrogenism.